HELLENIC ATHEROSCLEROSIS
SOCIETY

Criteria

Group 1 : Family History

First-degree relative with premature coronary heart disease First-degree relative with LDL-C >95th percentile by gender and age for country (>190 mg/dL; 4.9 mmol/L) First-degree relative with tendon xanthoma and/or corneal arcus Children aged <18 years with LDL-C >95th percentile by gender and age for country (>160 mg/dL; 4.1 mmol/L)

Group 2 : Personal Clinical History

Premature coronary heart disease Premature cerebrovascular or peripheral vascular disease

Group 3 : Physical Exam

Tendon xanthoma Corneal arcus in subject aged <45 yrs

Group 4 : LDL-C Level

>325 mg/dL (>8.5 mmol/L) 251-325 mg/dL (6.5-8.4 mmol/L) 191-250 mg/dL (5.0-6.4 mmol/L) 155-190 mg/dL (4.0-4.9 mmol/L)

Group 5 : Genetic Testing

Causative mutation in LDLR, ApoB, or PCSK9 genes